Elodie Ramond

Elodie Ramond is a post-doctoral researcher at the Necker-Enfants Malades Institute, working in the group Staphylococcus aureus since april 2018 under the supervision of Alain Charbit. Elodie joined the lab for the first time from 2011 to 2014 to carry out her PhD, still in Alain Charbit team. She studied the nutritional virulence aspects of the bacterium Francisella tularensis, and especially the importance of amino acids acquisition in its physiology and intracellular lifecycle. Then she performed her 1st postdoctoral studies at the Ecole Polytechnique Fédérale de Lausanne (Suisse), in Bruno Lemaitre laboratory, from november 2014 to march 2018. She worked on Drosophila melanogaster cellular immune response to bacterial challenges and macrophages physiology. Finally, she came back in the lab where she is setting up a Drosophila infection model with the multi resistant S. aureus bacterium USA300, with the aim to identify new virulence factors. In parallel, she collaborates with Anne Jamet on a more applied clinical project, trying to identify key factors that play a role in lung colonization specifically in patients with cystic fibrosis.

Last News of the Lab

Team Members

Last Publications

Ding, X, Robbe-Masselot, C, Fu, X, Léonard, R, Marsac, B, Dauriat, CJG et al.. Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle. Nat Commun. 2023;14 (1):8135. doi: 10.1038/s41467-023-43863-2. PubMed PMID:38065959 PubMed Central PMC10709412.
Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response. J Infect Dis. 2022;226 (7):1276-1285. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
Petrignani, B, Rommelaere, S, Hakim-Mishnaevski, K, Masson, F, Ramond, E, Hilu-Dadia, R et al.. A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila. EMBO Rep. 2021;22 (9):e52262. doi: 10.15252/embr.202052262. PubMed PMID:34370384 PubMed Central PMC8419693.
Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
Ramond, E, Dudzic, JP, Lemaitre, B. Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury. PLoS One. 2020;15 (6):e0235294. doi: 10.1371/journal.pone.0235294. PubMed PMID:32598400 PubMed Central PMC7323993.
Ramond, E, Petrignani, B, Dudzic, JP, Boquete, JP, Poidevin, M, Kondo, S et al.. The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila. FEBS J. 2020;287 (16):3399-3426. doi: 10.1111/febs.15237. PubMed PMID:32009293 .
Sanchez Bosch, P, Makhijani, K, Herboso, L, Gold, KS, Baginsky, R, Woodcock, KJ et al.. Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues. Dev Cell. 2019;51 (6):787-803.e5. doi: 10.1016/j.devcel.2019.10.017. PubMed PMID:31735669 PubMed Central PMC7263735.
Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
Melcarne, C, Ramond, E, Dudzic, J, Bretscher, AJ, Kurucz, É, Andó, I et al.. Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster. FEBS J. 2019;286 (14):2670-2691. doi: 10.1111/febs.14857. PubMed PMID:30993828 PubMed Central PMC6852320.
Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
Ramond, E, Maclachlan, C, Clerc-Rosset, S, Knott, GW, Lemaitre, B. Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii. mBio. 2016;7 (4):. doi: 10.1128/mBio.00881-16. PubMed PMID:27460796 PubMed Central PMC4981714.
Brissac, T, Ziveri, J, Ramond, E, Tros, F, Kock, S, Dupuis, M et al.. Gluconeogenesis, an essential metabolic pathway for pathogenic Francisella. Mol Microbiol. 2015;98 (3):518-34. doi: 10.1111/mmi.13139. PubMed PMID:26192619 .
Ramond, E, Meister, M, Lemaitre, B. From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle. Dev Cell. 2015;33 (4):367-8. doi: 10.1016/j.devcel.2015.05.002. PubMed PMID:26017766 .
Hénique, C, Mansouri, A, Vavrova, E, Lenoir, V, Ferry, A, Esnous, C et al.. Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. FASEB J. 2015;29 (6):2473-83. doi: 10.1096/fj.14-257717. PubMed PMID:25713059 .
Barel, M, Ramond, E, Gesbert, G, Charbit, A. The complex amino acid diet of Francisella in infected macrophages. Front Cell Infect Microbiol. 2015;5 :9. doi: 10.3389/fcimb.2015.00009. PubMed PMID:25705612 PubMed Central PMC4319460.
Ramond, E, Gesbert, G, Guerrera, IC, Chhuon, C, Dupuis, M, Rigard, M et al.. Importance of host cell arginine uptake in Francisella phagosomal escape and ribosomal protein amounts. Mol Cell Proteomics. 2015;14 (4):870-81. doi: 10.1074/mcp.M114.044552. PubMed PMID:25616868 PubMed Central PMC4390266.
Gesbert, G, Ramond, E, Tros, F, Dairou, J, Frapy, E, Barel, M et al.. Importance of branched-chain amino acid utilization in Francisella intracellular adaptation. Infect Immun. 2015;83 (1):173-83. doi: 10.1128/IAI.02579-14. PubMed PMID:25332124 PubMed Central PMC4288867.
Ramond, E, Gesbert, G, Rigard, M, Dairou, J, Dupuis, M, Dubail, I et al.. Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape. PLoS Pathog. 2014;10 (1):e1003893. doi: 10.1371/journal.ppat.1003893. PubMed PMID:24453979 PubMed Central PMC3894225.
Gesbert, G, Ramond, E, Rigard, M, Frapy, E, Dupuis, M, Dubail, I et al.. Asparagine assimilation is critical for intracellular replication and dissemination of Francisella. Cell Microbiol. 2014;16 (3):434-49. doi: 10.1111/cmi.12227. PubMed PMID:24134488 .

Search PubMed

Airway environment promote Staphylococcus aureus chronic lifestyle

Congratulation to Morgane Wuckelt and Elif UYAR

Genomic analysis of S. aureus sequential isolates

Lung-Adapted Staphylococcus aureus Trigger a Proinflammatory Response

The pentose phosphate pathway in pathogenic Francisella

Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

MRSA Virulence in a new Drosophila Larval Model

High resolution typing of Staphylococcus epidermidis

Chronic Staphylococcus Aureus Lung Infection Correlates With an Increased Intracellular Persistence